Immunochemical Properties of Recombinant Ompf Porin from Outer Membrane of Yersinia pseudotuberculosis
نویسندگان
چکیده
Porins from outer membranes (OM) of Gram-negative bacteria exist in intact membranes as homotrimers forming water-filled pores or channels that provide low-molecular compounds transportation. Surface localization of the porins and their structural peculiarities determine multiplicity of their functions except for the transport one. On the one hand, porins are targets for the host immune system. As the targets they activate factors of the organism fast protection and are involved in the formation of specific immune response. On the other hand, porins serve as the factors of pathogenesis and virulence inhibiting the first stage of the host immune system and providing survival of a pathogen in macroorganism. Porins are speciesand genus-specific antigens of Gram-negative bacteria and belong to the highly immunogenic OM components. The antibodies against the porins are found in blood sera both after vaccination and after natural development of infection.
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